99mTc-sestamibi uptake in rat skeletal muscle and heart: physiological determinants and correlations

(99m)Tc-sestamibi uptake in rat skeletal muscle and heart: physiological determinants and correlations.

The lipophilic cationic radiotracer (99m)Tc-sestamibi, known to be concentrated within mitochondria, is widely used for myocardial perfusion and to a lesser extent for muscle metabolism imaging. However, the exact distribution pattern in skeletal muscle has not been yet studied in detail. The present study aims to investigate the (99m)Tc-sestamibi uptake in rat skeletal muscle and myocardium in...

Uptake in Rat Skeletal Muscle and Heart: A Potential Physiological Explanation

99mTc-sestamibi uptake and retention during myocardial ischemia and reperfusion.

BACKGROUND 99mTc-methoxyisobutyl isonitrile (Sestamibi) is a new perfusion agent that has shown promise for the noninvasive detection of myocardial salvage after coronary reperfusion in acute myocardial infarction. The objective of this study was to further validate that myocardial uptake and retention of Sestamibi after reperfusion in a canine myocardial infarction model are markers of tissue ...

Effect of asiaticoside on 99mTc-tetrofosmin and 99mTc-sestamibi uptake in MCF-7 cells.

UNLABELLED This study was done to examine the effect of asiaticoside on MCF-7 cell uptake of (99m)Tc-tetrofosmin ((99m)Tc-Tfos) and (99m)Tc-sestamibi ((99m)Tc-MIBI). METHODS The 3-(4,5-dimethylthiozol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay was used to evaluate the effect of a 50% inhibitory concentration of asiaticoside on MCF-7 cell proliferation. MCF-7 cells were treated with 10,...

Correlations between Electron Microscopic and Physiological Observations in Heart Muscle

The contraction of vertebrate heart muscle differs in characteristic ways from that of skeletal muscle (Brady, 1967): cardiac muscle cannot be tetanized; it has a significant resting tension at lengths where normal contractile tension is developed, a resting tension which may be subject to certain self-regulatory control mechanisms; and it is characterized by a slow onset of contractility. Phys...